There are a few ways to set a default label size for your Prafia printer.
Normally, you can use Last Used Settings shown below as a preset to print. This will remember the setting that was previously used.
If this doesn't work, please follow these steps to set the default size in your operating system.
In the Print Prompt Window, under Paper Size, click on Manage Custom Sizes.
Click on the + to add a new size.
Create a new size with dimensions 4" x 6" or 100 mm x 150 mm. You can double-click on the name (left side) to rename it to "4x6", "100mm x 150mm", or something similar.
Go to System Preferences → Printers & Scanners, select your Prafia Printer, and set the default size to 4x6 or 100 mm x 150 mm.